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NGC 2506 is a rich, intermediate-age (2.0 Gyr), metal-poor ([Fe/H] ∼ -0.2) open cluster. This work presents the results of 12,157 spectroscopic radial-velocity measurements of 2442 stars in the NGC 2506 field obtained over 41 yr, made as part of the WIYN Open Cluster Study. Radial-velocity measurements are complete for the population of proper-motion member stars brighter than a Gaia G magnitude of 15.5, in which 320 proper-motion and radial-velocity cluster members were identified. Within the observation limit of G < 16.5, 469 proper-motion and radial-velocity members were identified. This work reports on the characteristics of NGC 2506, including projected spatial distribution, radial-velocity dispersion, and virial mass. This work also presents orbital solutions for 49 binary members with periods between 1 and 7580 days. NGC 2506 has an incompleteness-corrected binary frequency for binaries with periods less than 10⁴ days of 35% ± 5%. This work also discusses in detail the 14 blue stragglers stars of NGC 2506-finding at least 64% ± 21% to be in binaries, five yellow straggler stars, and several other stars of note.